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Why ss31 should precede mots c for better results

SS31 vs. Mots C | New Directions in Mitochondrial Supplementation

By

Elizabeth Stark

Sep 15, 2026, 01:30 PM

Edited By

Lara Johnson

Updated

Sep 16, 2026, 11:49 PM

Brief read

Illustration showing the sequence of SS31 and Mots C for cell repair
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A heated debate among health enthusiasts is questioning the necessity of taking SS-31 before Mots C. Recent discussions across user boards reveal that many feel there is insufficient clinical data to mandate the sequencing of these supplements.

Controversy Sparks Among Users

In various forums, users voiced skepticism, stating, "You don't need to do SS-31 before Mots. There are no clinical studies supporting that order." This sentiment reflects a growing frustration among those seeking clearer guidelines on mitochondrial health supplements.

Shifting Opinions on Supplementation Protocols

Another comment noted, "Dr. Jones' claims are anecdotal, based on theoretical concepts, with no human trials backing it." While some users insist on taking 2mg daily of SS-31 along with 10mg of Mots C three times weekly, others advocate for a rotation method: using 2 vials of Mots C followed by 1 vial of SS-31.

"I keep them on a rotation, it works out to 4 cycles per year," shared a participant.

User Experiences Reflect Variability

User reports showcase varied experiences:

  • Age Matters: Users over 40 have expressed benefits from SS-31, claiming improved energy and performance, while younger individuals report success without prior supplementation.

  • Common Symptoms: One user described ongoing fatigue in their third week of SS-31, suggesting the body is undergoing necessary mitochondrial repairs.

  • Trial and Error: "Whatโ€™s good for you could kill me," another asserted, underlining the personalized nature of these supplements.

Personalized Approaches and Key Insights

As people increasingly seek tailored health solutions, itโ€™s clear that individual responses to supplementation are crucial. Many emphasize the need for personal experimentation in protocols due to differing effects based on age, health conditions, and lifestyle.

  • ๐Ÿ”ˆ Users remained split on the necessity of the sequence between SS-31 and Mots C.

  • ๐Ÿ“ˆ Some have experienced a noted improvement in workout performance when combining both supplements.

  • โ“ Thereโ€™s a clear call for more clinically-backed testing to guide decisions around supplementation.